Endocrine Abstracts

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

Objective: The recommendations for action in a Bethesda category III are to repeat the cytology or to perform molecular tests, and if these are inconclusive, surveillance or surgical indication may be maintained, depending on the risk factors, ultrasound characteristics of the nodule and patient preference. In case of category IV of Bethesda, the recommendation is the surgery. The objective of this study was to evaluate the impact of age, gender and nodule size on the incidenc...

Objective: Thyroid cancer is the most common of the endocrine tumors, with papillary being the most frequent. There is no consensus about prophylactic central cervical dissection in patients with papillary carcinoma of the thyroid. The aim of this study is to analyze surgical complications and the rate of recurrence of papillary carcinoma in patients undergoing total thyroidectomy and prophylactic central cervical dissection, and patients submitted to total thyroidectomy alone...

Introduction: Incidental papillary thyroid carcinoma (PTC) in patients undergoing thyroidectomy for benign multinodular disease is a well-recognised finding. Its true prevalence remains uncertain and shows great variability between studies, ranging from 7–25%. Our purpose was to review the prevalence of PTC in thyroid glands removed for benign nodular disease at a Northern Portuguese tertiary hospital.Methods: From December 2012 to December 2014, th...

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). First-line treatment is radical removal of the primary tumour; however, management of metastatic BC is still challenging. Bronchial carcinoids (BC) may benefit from treatment with mTOR inhibitors, although response rates are moderate. TBC have shown reduced sensibility to mTOR inhibitors respect to ABC, notwithstanding its less aggressive behaviour. PI3...

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

Introduction: Thyroid nodules (TN) are common entities usually discovered during a physical exam or by chance with ultrasound (US) procedures performed for reasons different from thyroid check. The majority of nodules are benign, notwithstanding the growing incidence of thyroid cancer (TC), which increases much largely as compared to all other tumours each year and will be, presumably, the most incident malignancy in women after breast cancer. The clinical challenge relies on ...

Hypophagia and increased energy expenditure under inflammatory condition, such as observed after bacterial lipopolysaccharide (LPS) administration, are associated with activation of JAK2–STAT3 signaling in the CNS. High fat diet (HFD) is known to induce hypothalamic resistance to leptin signaling mediated by JAK2–STAT3 pathway. In this study we investigated the expression of p-STAT3 in the hypothalamus and brainstem of HFD treated animals under LPS (100 μg/kg) s...